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In recent years, GIP/GLP-1 receptor dual agonists and GIP/GLP-1/glucagon receptor triple agonists, which co-stimulate multiple hormone receptors including GIPR, continue to be reported to exert remarkable anti-obesity and hypoglycaemic effects when compared to agonists of the GLP-1R alone, and are now being applied in clinical practice
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However, challenges remain in optimizing treatment outcomes, addressing patient variability, and improving long-term adherence
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